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Article

Structural and mechanistic insights into Mps1 kinase activation.

Journal of cellular and molecular medicine - 1 Aug 2009

Wang Wei, Yang Yuting, Gao Yuefeng, Xu Quanbin, Wang Feng, Zhu Songcheng, Old William, Resing Katheryn, Ahn Natalie, Lei Ming, Liu Xuedong

Abstract excerpt

Mps1 is one of the several essential kinases whose activation is required for robust mitotic spindle checkpoint signalling. The activity of Mps1 is tightly regulated and increases dramatically during mitosis or in response to spindle damage. To understand the molecular mechanism underlying Mps1 regulation, we determined the crystal structure of the kinase domain of Mps1. The 2.7-A-resolution crystal structure...

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Identifiers

PMID: 19120698
DOI: 10.1111/j.1582-4934.2008.00605.x
PMCID: PMC2829362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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