Article

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures

2017-02-27

Abstract excerpt

Monopolar spindle 1 (Mps1/TTK) is a protein kinase essential in mitotic checkpoint signalling, preventing anaphase until all chromosomes are properly attached to spindle microtubules. Mps1 has emerged as a potential target for cancer therapy, and a variety of compounds have been developed to inhibit its kinase activity. Mutations in the catalytic domain of Mps1 that give rise to inhibitor resistance, but retain ca...

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Literature Corpus work: b517bb27-32d9-5902-b9a1-7583d4137b4f
DOI: 10.1101/112086

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