Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphoregulation of human Mps1 kinase.

The Biochemical journal - 1 Jan 2009

Tyler Rebecca K, Chu Matthew L H, Johnson Hannah, McKenzie Edward A, Gaskell Simon J, Eyers Patrick A

Abstract excerpt

The dual-specificity protein kinase Mps1 (monopolar spindle 1) is a phosphoprotein required for error-free mitotic progression in eukaryotes. In the present study, we have investigated human Mps1 phosphorylation using combined mass spectrometric, mutational and phosphospecific antibody approaches. We have identified 16 sites of Mps1 autophosphorylation in vitro, several of which are required for catalytic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Cell Cycle Proteins
Share to Centrosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Mitosis

Share to Protein Structure, Secondary

Share to Protein-Tyrosine Kinases

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 18680479
DOI: 10.1042/BJ20081310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphoregulation of human Mps1 kinase.PMID 18680479Read ↗

Mps1 activation loop autophosphorylation enhances kinase activity.Semantic proximity Read ↗

The MPS1 Family of Protein KinasesSemantic proximity Read ↗

Structural and mechanistic insights into Mps1 kinase activation.Semantic proximity Read ↗

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression.Semantic proximity Read ↗

Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.Semantic proximity Read ↗

Preventing the Degradation of Mps1 at Centrosomes Is Sufficient to Cause Centrosome Reduplication in Human CellsSemantic proximity Read ↗

Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging ChromosomesSemantic proximity Read ↗

N-terminal regions of Mps1 kinase determine functional bifurcation.Semantic proximity Read ↗

Development of MPS1 Inhibitors: Recent Advances and PerspectivesSemantic proximity Read ↗

Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylationSemantic proximity Read ↗

Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 KinaseSemantic proximity Read ↗

Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in MitosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.