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Development of MPS1 Inhibitors: Recent Advances and Perspectives

14 Dec 2023

Abstract excerpt

Monopolar spindle kinase 1 (MPS1) plays a pivotal role as a dual-specificity kinase governing spindle assembly checkpoint activation and sister chromatid separation in mitosis. Its overexpression has been observed in various human malignancies. MPS1 reduces spindle assembly checkpoint sensitivity, allowing tumor cells with a high degree of aneuploidy to complete mitosis and survive. Thus, MPS1 has emerged as a...

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PMID: 38095579
DOI: 10.1021/acs.jmedchem.3c00963

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