Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mps1 activation loop autophosphorylation enhances kinase activity.

The Journal of biological chemistry - 19 Oct 2007

Mattison Christopher P, Old William M, Steiner Estelle, Huneycutt Brenda J, Resing Katheryn A, Ahn Natalie G, Winey Mark

Abstract excerpt

The Mps1 protein kinase is required for proper assembly of the mitotic spindle, checkpoint signaling, and several other aspects of cell growth and differentiation. Mps1 regulation is mediated by cell cycle-dependent changes in transcription and protein level. There is also a strong correlation between hyperphosphorylated mitotic forms of Mps1 and increased kinase activity. We investigated the role that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Centrosome
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mass Spectrometry

Share to Protein Processing, Post-Translational

Share to Protein-Tyrosine Kinases

Share to Spindle Apparatus

Share to Threonine

Source

Identifiers

PMID: 17728254
DOI: 10.1074/jbc.M707063200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mps1 activation loop autophosphorylation enhances kinase activity.PMID 17728254Read ↗

Phosphoregulation of human Mps1 kinase.Semantic proximity Read ↗

Structural and mechanistic insights into Mps1 kinase activation.Semantic proximity Read ↗

The MPS1 Family of Protein KinasesSemantic proximity Read ↗

Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.Semantic proximity Read ↗

New alleles of the yeast MPS1 gene reveal multiple requirements in spindle pole body duplication.Semantic proximity Read ↗

N-terminal regions of Mps1 kinase determine functional bifurcation.Semantic proximity Read ↗

Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging ChromosomesSemantic proximity Read ↗

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression.Semantic proximity Read ↗

Preventing the Degradation of Mps1 at Centrosomes Is Sufficient to Cause Centrosome Reduplication in Human CellsSemantic proximity Read ↗

Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylationSemantic proximity Read ↗

Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.Semantic proximity Read ↗

Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.