Article
Role of increased ROS dissipation in prevention of T1D.
Annals of the New York Academy of Sciences - 1 Dec 2008
Chen Jing, Gusdon Aaron M, Thayer Terri C, Mathews Clayton E
Abstract excerpt
Protection of pancreatic beta cells is an approach to prevent autoimmune type 1 diabetes (T1D) and to protect transplanted islets. Reactive oxygen species (ROS) are important mediators of beta cell death during the development of T1D. We have examined the role of elevated ROS dissipation in the prevention of T1D using the ALR mouse strain. The selection of ALR, for resistance against alloxan-induced free...
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