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Article

Differential endocrine responses to rosiglitazone therapy in new mouse models of type 2 diabetes.

Endocrinology - 1 Feb 2006

Leiter Edward H, Reifsnyder Peter C, Zhang Weidong, Pan Huei-Ju, Xiao Qiang, Mistry Jehangir

Abstract excerpt

Polygenic mouse models for obesity-induced type 2 diabetes (T2D) more accurately reflect the most common manifestations of the human disease. Two inbred mouse strains (NON/Lt and NZO/HlLt) separately contributed T2D susceptibility- conferring quantitative trait loci to F1 males. Although chronic administration of rosiglitazone (Rosi) in diet (50 mg/kg) effectively suppressed F1 diabetes, hepatosteatosis was an...

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Source

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PMID: 16254032
DOI: 10.1210/en.2005-0839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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