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Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1C polymorphism.

Alcoholism, clinical and experimental research - 1 Mar 2009

Homann Nils, König Inke R, Marks Michael, Benesova Monika, Stickel Felix, Millonig Gunda, Mueller Sebastian, Seitz Helmut K

Abstract excerpt

BACKGROUND: Chronic alcohol consumption is a risk factor for colorectal cancer. Animal experiments as well as genetic linkage studies in Japanese individuals with inactive acetaldehyde dehydrogenase leading to elevated acetaldehyde concentrations following ethanol ingestion support the hypothesis that acetaldehyde may be responsible for this carcinogenic effect of alcohol. In Caucasians, a polymorphism of alcohol...

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Identifiers

PMID: 19120062
DOI: 10.1111/j.1530-0277.2008.00868.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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