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Article

Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers.

International journal of cancer - 15 Apr 2006

Homann Nils, Stickel Felix, König Inke R, Jacobs Arne, Junghanns Klaus, Benesova Monika, Schuppan Detlef, Himsel Susanne, Zuber-Jerger Ina, Hellerbrand Claus, Ludwig Dieter, Caselmann Wolfgang H, Seitz Helmut K

Abstract excerpt

Chronic alcohol consumption is associated with an increased risk for upper aerodigestive tract cancer and hepatocellular carcinoma. Increased acetaldehyde production via alcohol dehydrogenase (ADH) has been implicated in the pathogenesis. The allele ADH1C*1 of ADH1C encodes for an enzyme with a high capacity to generate acetaldehyde. So far, the association between the ADH1C*1 allele and alcohol-related cancers...

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Identifiers

PMID: 16287084
DOI: 10.1002/ijc.21583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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