Article
Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde.
Gut - 1 Jun 2004
Visapää J P, Götte K, Benesova M, Li J, Homann N, Conradt C, Inoue H, Tisch M, Hörrmann K, Väkeväinen S, Salaspuro M, Seitz H K
Abstract excerpt
BACKGROUND: Chronic ethanol consumption is associated with an increased risk of upper aerodigestive tract cancer. As acetaldehyde seems to be a carcinogenic factor associated with chronic alcohol consumption, alcoholics with the alcohol dehydrogenase (ADH) 1C*1 allele seem to be particularly at risk as this allele encodes for a rapidly ethanol metabolising enzyme leading to increased acetaldehyde levels. Recent...
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