Article
An analytical model for determining two-dimensional receptor-ligand kinetics.
Biophysical journal - 18 May 2011
Cheung Luthur Siu-Lun, Konstantopoulos Konstantinos
Abstract excerpt
Cell-cell adhesive interactions play a pivotal role in major pathophysiological vascular processes, such as inflammation, infection, thrombosis, and cancer metastasis, and are regulated by hemodynamic forces generated by blood flow. Cell adhesion is mediated by the binding of receptors to ligands, which are both anchored on two-dimensional (2-D) membranes of apposing cells. Biophysical assays have been developed...
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