Article
Life history of cones in the rhodopsin-mutant P23H-3 rat: evidence of long-term survival.
Investigative ophthalmology & visual science - 1 May 2009
Chrysostomou Vicki, Stone Jonathan, Valter Krisztina
Abstract excerpt
PURPOSE: To follow the status of cones over the life of the P23H-3 transgenic rat, while the rod population is depleted. METHODS: P23H-3 heterozygous and Sprague-Dawley (SD) control rats were raised in dim, cyclic light from postnatal day (P)10 to P540. Retinas were examined for cone density, cone outer segment (OS) length, cone axon and soma morphology, and the amplitude of rod and cone components of the...
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