Article
Genotypic and phenotypic characterization of P23H line 1 rat model.
PloS one - 1 Jan 2015
Orhan Elise, Dalkara Deniz, Neuillé Marion, Lechauve Christophe, Michiels Christelle, Picaud Serge, Léveillard Thierry, Sahel José-Alain, Naash Muna I, Lavail Matthew M, Zeitz Christina, Audo Isabelle
Abstract excerpt
Rod-cone dystrophy, also known as retinitis pigmentosa (RP), is the most common inherited degenerative photoreceptor disease, for which no therapy is currently available. The P23H rat is one of the most commonly used autosomal dominant RP models. It has been created by incorporation of a mutated mouse rhodopsin (Rho) transgene in the wild-type (WT) Sprague Dawley rat. Detailed genetic characterization of this...
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