Article
Enhanced cone dysfunction in rats homozygous for the P23H rhodopsin mutation.
Neuroscience letters - 1 Jan 2000
Pinilla I, Lund R D, Sauvé Y
Abstract excerpt
The heterozygous P23H transgenic rat is a model of autosomal dominant retinitis pigmentosa, in which a mutation in the rhodopsin gene leads to a rapid loss of rods and a more protracted loss of cones. It has been suggested that rods play an essential role in preserving cones. We tested this hypothesis by examining whether higher levels of dysfunctional rhodopsin in rats homozygous for the P23H mutation would...
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