Article
Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene.
Investigative ophthalmology & visual science - 1 Jan 1995
Goto Y, Peachey N S, Ripps H, Naash M I
Abstract excerpt
PURPOSE: To evaluate the consequences of the expression of a mutant mouse opsin gene on rod- and cone-mediated function. Experimental conditions were chosen to provide a basis of comparison to the results reported for patients with autosomal dominant retinitis pigmentosa (ADRP) in whom the prolin...
Topics
- Animals
- Dark Adaptation
- Densitometry
- Disease Models, Animal
- Electroretinography
- Gene Expression
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Mutation
- Photoreceptor Cells
- Retinitis Pigmentosa
- Rhodopsin
- Rod Opsins