Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene.

Investigative ophthalmology & visual science - 1 Jan 1995

Goto Y, Peachey N S, Ripps H, Naash M I

Abstract excerpt

PURPOSE: To evaluate the consequences of the expression of a mutant mouse opsin gene on rod- and cone-mediated function. Experimental conditions were chosen to provide a basis of comparison to the results reported for patients with autosomal dominant retinitis pigmentosa (ADRP) in whom the proline at position 23 has been replaced by a histidine (P23H). METHODS: The mutated gene product resulted in three...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Gene Expression
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Mice, Transgenic

Share to Mutation

Share to Photoreceptor Cells

Share to Retinitis Pigmentosa

Source

Identifiers

PMID: 7822160

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene.PMID 7822160Read ↗

Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa.Semantic proximity Read ↗

Polygenic disease and retinitis pigmentosa: albinism exacerbates photoreceptor degeneration induced by the expression of a mutant opsin in transgenic mice.Semantic proximity Read ↗

Xenopus laevis P23H rhodopsin transgene causes rod photoreceptor degeneration that is more severe in the ventral retina and is modulated by light.Semantic proximity Read ↗

Mutant rhodopsin transgene expression on a null background.Semantic proximity Read ↗

A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin.Semantic proximity Read ↗

Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa.Semantic proximity Read ↗

Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration.Semantic proximity Read ↗

Mouse models of human retinal disease caused by expression of mutant rhodopsin. A valuable tool for the assessment of novel gene therapies.Semantic proximity Read ↗

Enhanced cone dysfunction in rats homozygous for the P23H rhodopsin mutation.Semantic proximity Read ↗

Generation of a Transgenic Rabbit Model of Retinal DegenerationSemantic proximity Read ↗

Dark rearing rescues P23H rhodopsin-induced retinal degeneration in a transgenic Xenopus laevis model of retinitis pigmentosa: a chromophore-dependent mechanism characterized by production of N-terminally truncated mutant rhodopsin.Semantic proximity Read ↗

Retinoid kinetics in eye tissues of VPP transgenic mice and their normal littermates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.