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Article

The status of cones in the rhodopsin mutant P23H-3 retina: light-regulated damage and repair in parallel with rods.

Investigative ophthalmology & visual science - 1 Mar 2008

Chrysostomou Vicki, Stone Jonathan, Stowe Sally, Barnett Nigel L, Valter Krisztina

Abstract excerpt

PURPOSE: This study tests whether cones in the rhodopsin-mutant transgenic P23H-3 retina are damaged by ambient light and whether subsequent light restriction allows repair of damaged cones. METHODS: P23H-3 rats were raised in scotopic cyclic (12 hours of 5 lux, 12 hours of dark) ambient light. At postnatal day 90 to 130, some were transferred to photopic conditions (12 hours of 300 lux, 12 hours of dark) for 1...

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Identifiers

PMID: 18326739
DOI: 10.1167/iovs.07-1158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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