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Article

Identification of the core element responsive to runt‐related transcription factor 2 in the promoter of human type x collagen gene

30 Dec 2008

Abstract excerpt

OBJECTIVE: Type X collagen and runt-related transcription factor 2 (RUNX-2) are known to be important for chondrocyte hypertrophy during skeletal growth and repair and development of osteoarthritis (OA) in mice. Aiming at clinical application, this study was undertaken to investigate transcriptional regulation of human type X collagen by RUNX-2 in human cells. METHODS: Localization of type X collagen and RUNX-2...

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PMID: 19116917
DOI: 10.1002/art.24243

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