Article

A Synthetic, Closed-Looped Gene Circuit for the Autonomous Regulation of RUNX2 Activity during Chondrogenesis

2021-04-20

Abstract excerpt

The transcription factor RUNX2 is a key regulator of chondrocyte phenotype during development, making it an ideal target for prevention of undesirable chondrocyte maturation in cartilage tissue engineering strategies. Here, we engineered an autoregulatory gene circuit ( cis CXp-sh Runx2 ) that negatively controls RUNX2 activity in chondrogenic cells via RNA interference initiated by a tunable synthetic Col10a1...

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Literature Corpus work: ac019512-da1a-513a-8bef-858bcb2b9ad1
DOI: 10.1101/2021.04.20.440669

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