Sic1-induced DNA rereplication during meiosis.

doi:10.1073/pnas.0809731105

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Sic1-induced DNA rereplication during meiosis.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2009

Sawarynski Kara E, Najor Nicole A, Kepsel Andrea C, Brush George S

Abstract excerpt

Orderly progression through meiosis requires strict regulation of DNA metabolic events, so that a single round of DNA replication is systematically followed by a recombination phase and 2 rounds of chromosome segregation. We report here the disruption of this sequence of events in Saccharomyces cerevisiae through meiosis-specific induction of the cyclin-dependent kinase (CDK) inhibitor Sic1 mutated at multiple...

Topics

CDC28 Protein Kinase, S cerevisiae
Cell Cycle Proteins
Chromosome Segregation
Cyclin-Dependent Kinase Inhibitor Proteins
DNA Replication
DNA-Binding Proteins
Meiosis
Mutation
Pachytene Stage
Phosphorylation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 19116279
DOI: 10.1073/pnas.0809731105
PMCID: PMC2629211

Genes

DMC1
RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics