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Article

Sic1-induced DNA rereplication during meiosis.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2009

Sawarynski Kara E, Najor Nicole A, Kepsel Andrea C, Brush George S

Abstract excerpt

Orderly progression through meiosis requires strict regulation of DNA metabolic events, so that a single round of DNA replication is systematically followed by a recombination phase and 2 rounds of chromosome segregation. We report here the disruption of this sequence of events in Saccharomyces cerevisiae through meiosis-specific induction of the cyclin-dependent kinase (CDK) inhibitor Sic1 mutated at multiple...

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Source

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Identifiers

PMID: 19116279
DOI: 10.1073/pnas.0809731105
PMCID: PMC2629211

Genes

DMC1
RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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