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Article

Down-regulation of Rad51 activity during meiosis in yeast prevents competition with Dmc1 for repair of double-strand breaks.

PLoS genetics - 1 Jan 2014

Liu Yan, Gaines William A, Callender Tracy, Busygina Valeria, Oke Ashwini, Sung Patrick, Fung Jennifer C, Hollingsworth Nancy M

Abstract excerpt

Interhomolog recombination plays a critical role in promoting proper meiotic chromosome segregation but a mechanistic understanding of this process is far from complete. In vegetative cells, Rad51 is a highly conserved recombinase that exhibits a preference for repairing double strand breaks (DSBs) using sister chromatids, in contrast to the conserved, meiosis-specific recombinase, Dmc1, which preferentially...

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Share to Chromatids
Share to Chromosome Segregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Gene Expression Regulation, Fungal

Share to Homologous Recombination

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Source

Open in PubMed Open full text

Identifiers

PMID: 24465215
DOI: 10.1371/journal.pgen.1004005
PMCID: PMC3900393

Genes

DMC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Down-regulation of Rad51 activity during meiosis in yeast prevents competition with Dmc1 for repair of double-strand breaks.PMID 24465215Read ↗

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