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Article

Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.

Molecular and cellular biology - 1 Mar 2009

Yanagiya Akiko, Svitkin Yuri V, Shibata Shoichiro, Mikami Satoshi, Imataka Hiroaki, Sonenberg Nahum

Abstract excerpt

Eukaryotic mRNAs possess a 5'-terminal cap structure (cap), m(7)GpppN, which facilitates ribosome binding. The cap is bound by eukaryotic translation initiation factor 4F (eIF4F), which is composed of eIF4E, eIF4G, and eIF4A. eIF4E is the cap-binding subunit, eIF4A is an RNA helicase, and eIF4G is a scaffolding protein that bridges between the mRNA and ribosome. eIF4G contains an RNA-binding domain, which was...

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Identifiers

PMID: 19114555
DOI: 10.1128/MCB.01187-08
PMCID: PMC2648241

Genes

RRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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