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Identification in the ancient protist Giardia lamblia of two eukaryotic translation initiation factor 4E homologues with distinctive functions.

Eukaryotic cell - 1 May 2005

Li Lei, Wang Ching C

Abstract excerpt

Eukaryotic translation initiation factor 4E (eIF4E) binds to the m(7)GTP of capped mRNAs and is an essential component of the translational machinery that recruits the 40S small ribosomal subunit. We describe here the identification and characterization of two eIF4E homologues in an ancient protist, Giardia lamblia. Using m(7)GTP-Sepharose affinity column chromatography, a specific binding protein was isolated...

Topics

Amino Acid Sequence
Animals
Eukaryotic Initiation Factor-4E
Genetic Complementation Test
Giardia lamblia
Molecular Sequence Data
Mutation
Phylogeny
Protein Biosynthesis
Protozoan Proteins
RNA Caps

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Sequence Alignment

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Identifiers

PMID: 15879529
DOI: 10.1128/EC.4.5.948-959.2005
PMCID: PMC1140097

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