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Article

Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs.

Genes & development - 1 Jul 2016

Kumar Parimal, Hellen Christopher U T, Pestova Tatyana V

Abstract excerpt

Ribosomal attachment to mammalian capped mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S chain of interactions, but the mechanism by which mRNA enters the mRNA-binding channel of the 40S subunit remains unknown. To investigate this process, we recapitulated initiation on capped mRNAs in vitro using a reconstituted translation system. Formation of initiation complexes at...

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Identifiers

PMID: 27401559
DOI: 10.1101/gad.282418.116
PMCID: PMC4949329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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