Article
Genetic alterations within the retinoblastoma locus in colorectal carcinomas. Relation to DNA ploidy pattern studied by flow cytometric analysis.
British journal of cancer - 1 Sept 1991
Meling G I, Lothe R A, Børresen A L, Hauge S, Graue C, Clausen O P, Rognum T O
Abstract excerpt
Alterations within the retinoblastoma (Rb) gene, as detected by the VNTR probe p68RS2.0, and flow cytometric DNA pattern have been analysed in 255 colorectal carcinomas. A total of 35.3% of the tumours had alterations within the Rb gene. Amplification of one allele was demonstrated in 29.5% of th...
Topics
- Alleles
- Blotting, Southern
- Colonic Neoplasms
- DNA Probes
- DNA, Neoplasm
- Female
- Flow Cytometry
- Genes, Retinoblastoma
- Humans
- Male
- Neoplasm Staging
- Ploidies
- Rectal Neoplasms
- Restriction Mapping