Article
The relationship of DNA aneuploidy to molecular genetic alterations in colorectal carcinoma.
Gastroenterology - 1 May 1992
Offerhaus G J, De Feyter E P, Cornelisse C J, Tersmette K W, Floyd J, Kern S E, Vogelstein B, Hamilton S R
Abstract excerpt
Altered total nuclear DNA content is frequent in colorectal carcinomas, but the mechanisms producing aneuploidy are unknown. Therefore, DNA ploidy by flow cytometry was correlated with molecular genetic alterations and tumor characteristics in 50 colorectal carcinomas. The prognostic value of these alterations was also evaluated because aneuploidy has been associated with poor prognosis. Thirty-nine of the...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aneuploidy
- Colorectal Neoplasms
- DNA, Neoplasm
- Female
- Genes, ras
- Humans
- Male
- Middle Aged
- Mutation