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Article

Generation and characterization of a novel, permanently active S100P mutant.

Biochimica et biophysica acta - 1 Jun 2009

Austermann Judith, Nazmi Ali Reza, Heil Annika, Fritz Günter, Kolinski Michal, Filipek Slawomir, Gerke Volker

Abstract excerpt

S100 proteins function as Ca2+ signal transducers by regulating cellular targets in their Ca2+ bound conformation. S100P is a member of the S100 protein family that can activate the membrane and F-actin binding protein ezrin in a Ca2+ dependent manner at least in vitro. Here we generated a novel tool to elucidate directly the S100P-ezrin interaction in vivo. This was achieved by constructing a S100P derivative...

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Identifiers

PMID: 19111582
DOI: 10.1016/j.bbamcr.2008.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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