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Article

The C-terminal random coil region tunes the Ca²⁺-binding affinity of S100A4 through conformational activation.

PloS one - 1 Jan 2014

Duelli Annette, Kiss Bence, Lundholm Ida, Bodor Andrea, Petoukhov Maxim V, Svergun Dmitri I, Nyitray László, Katona Gergely

Abstract excerpt

S100A4 interacts with many binding partners upon Ca2+ activation and is strongly associated with increased metastasis formation. In order to understand the role of the C-terminal random coil for the protein function we examined how small angle X-ray scattering of the wild-type S100A4 and its C-terminal deletion mutant (residues 1-88, Δ13) changes upon Ca2+ binding. We found that the scattering intensity of...

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Identifiers

PMID: 24830809
DOI: 10.1371/journal.pone.0097654
PMCID: PMC4022583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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