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Article

Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity.

Journal of molecular biology - 16 Jun 2006

Leukert Nadja, Vogl Thomas, Strupat Kerstin, Reichelt Rudolf, Sorg Clemens, Roth Johannes

Abstract excerpt

S100 proteins comprise the largest family of calcium-binding proteins. Members of this family usually form homo- or heterodimers, which may associate to higher-order oligomers in a calcium-dependent manner. The heterodimers of S100A8 and S100A9 represent the major calcium-binding proteins in phagocytes. Both proteins regulate migration of these cells via modulation of tubulin polymerization. Calcium binding...

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Source

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PMID: 16690079
DOI: 10.1016/j.jmb.2006.04.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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