S100A9 interacts with a dynamic region on CD14 to activate Toll-like receptor 4

Abstract excerpt

S100A9 is a Damage Associated Molecular Pattern (DAMP) that activates inflammatory pathways via Toll-like receptor 4 (TLR4). This activity plays important homeostatic roles in tissue repair, but can also contribute to inflammatory diseases. The mechanism of activation is unknown. Here, we follow up on a previous observation that the protein CD14 is an important co-receptor that enables S100A9 to activate TLR4. Usi...

Topics

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• Calcium-Binding Proteins
• Caspase 3
• Caspase 9
• Immune Response and Inflammation
• MAP Kinase Signaling System
• Neonatal Respiratory Health Research
• NF-kappa B
• S100 Proteins and Annexins

Identifiers and source

Literature Corpus work

44876ea9-bf56-5f05-9df7-7a1f17a20d0a

DOI

10.1101/2024.05.15.594416