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Article

Structure of the S100A4/myosin-IIA complex.

BMC structural biology - 20 Nov 2013

Ramagopal Udupi A, Dulyaninova Natalya G, Varney Kristen M, Wilder Paul T, Nallamsetty Sridevi, Brenowitz Michael, Weber David J, Almo Steven C, Bresnick Anne R

Abstract excerpt

BACKGROUND: S100A4, a member of the S100 family of Ca2+-binding proteins, modulates the motility of both non-transformed and cancer cells by regulating the localization and stability of cellular protrusions. Biochemical studies have demonstrated that S100A4 binds to the C-terminal end of the myosin-IIA heavy chain coiled-coil and disassembles myosin-IIA filaments; however, the mechanism by which S100A4 mediates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24252706
DOI: 10.1186/1472-6807-13-31
PMCID: PMC3924328

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