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Article

Inactivation of BRCA1 and BRCA2 in ovarian cancer.

Journal of the National Cancer Institute - 18 Sept 2002

Hilton Jeffrey L, Geisler John P, Rathe Jennifer A, Hattermann-Zogg Melanie A, DeYoung Barry, Buller Richard E

Abstract excerpt

BACKGROUND: Although BRCA1 and BRCA2 play important roles in hereditary ovarian cancers, the extent of their role in sporadic ovarian cancers and their mechanisms of inactivation are not yet well understood. Our goal was to characterize BRCA2 mutations and mRNA expression in a group of ovarian tumors previously evaluated for BRCA1 mutations and mRNA expression. METHODS: The tumors of 92 unrelated women with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12237285
DOI: 10.1093/jnci/94.18.1396

Genes

BRCA2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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