Article
Sporadic breast carcinomas with somatic BRCA1 gene deletions share genotype/phenotype features with familial breast carcinomas.
Anticancer research - 1 Sept 2010
Rhiem Kerstin, Todt Unda, Wappenschmidt Barbara, Klein Annette, Wardelmann Eva, Schmutzler Rita K
Abstract excerpt
BACKGROUND: High frequencies of loss of heterozygosity (LOH) are found in familial breast carcinomas with BRCA mutations. Although LOH of BRCA1 does not coincide with somatic BRCA1 mutations, reduced BRCA1 protein expression and hypermethylation indicate the involvement of BRCA1 in sporadic carci...
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