Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2008

Walsh Christine S, Ogawa Seishi, Scoles Daniel R, Miller Carl W, Kawamata Norihiko, Narod Steven A, Koeffler H Phillip, Karlan Beth Y

Abstract excerpt

PURPOSE: The importance of the BRCA gene products in maintaining genomic stability led us to hypothesize that BRCA-associated and sporadic ovarian cancers would have distinctive genetic profiles despite similarities in histologic appearance. EXPERIMENTAL DESIGN: A whole-genome copy number analysis of fresh, frozen, papillary serous ovarian cancer DNA was done using the Affymetrix 50K Xba Mapping Array using each...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Loss of Heterozygosity

Share to Oligonucleotide Array Sequence Analysis

Share to Ovarian Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Uniparental Disomy

Source

Open in PubMed Open full text

Identifiers

PMID: 19047089
DOI: 10.1158/1078-0432.CCR-08-1291
PMCID: PMC2677417

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas.PMID 19047089Read ↗

Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation.Semantic proximity Read ↗

High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications.Semantic proximity Read ↗

Allele Imbalance, or Loss of Heterozygosity, in Normal Breast Epithelium of Sporadic Breast Cancer Cases and BRCA1 Gene Mutation Carriers Is Increased Compared With Reduction Mammoplasty TissuesSemantic proximity Read ↗

Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization.Semantic proximity Read ↗

Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers.Semantic proximity Read ↗

Genomic Instability Within Tumor Stroma and Clinicopathological Characteristics of Sporadic Primary Invasive Breast CarcinomaSemantic proximity Read ↗

[Inactivation of BRCA1, BRCA2 and p53 genes in sporadic ovarian cancer].Semantic proximity Read ↗

Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancerSemantic proximity Read ↗

Gene and chromosomal alterations in sporadic breast cancer: correlation with histopathological features and implications for genesis and progression.Semantic proximity Read ↗

Genomewide scan for loss of heterozygosity and chromosomal amplification in breast carcinoma using single-nucleotide polymorphism arrays.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 13q12-q14, BRCA-2 mutations and lack of BRCA-2 promoter hypermethylation in sporadic epithelial ovarian tumors.Semantic proximity Read ↗

Pathogenesis and consequences of uniparental disomy in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.