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Article

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation.

Blood - 26 Feb 2009

Bonder Claudine S, Sun Wai Y, Matthews Tyson, Cassano Carlos, Li Xiaochun, Ramshaw Hayley S, Pitson Stuart M, Lopez Angel F, Coates P Toby, Proia Richard L, Vadas Mathew A, Gamble Jennifer R

Abstract excerpt

Circulating endothelial progenitor cells (EPCs) are incorporated into foci of neovascularization where they undergo differentiation to mature endothelial cells (ECs). We show here that the enzyme sphingosine kinase-1 (SK-1) regulates the rate and direction of EPC differentiation without effect on the hematopoietic compartment. EPCs have high levels of SK-1 activity, which diminishes with differentiation and is,...

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Identifiers

PMID: 19109558
DOI: 10.1182/blood-2008-07-166942
PMCID: PMC2651020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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