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DHCR24 Regulates Endothelial Senescence through the SPHK2/SPNS2-S1P Axis

2026-07-20

Abstract excerpt

<title>Abstract</title> <p> Vascular endothelial senescence is a pivotal driver of age-related pathologies. Metabolism plays a critical regulatory role in endothelial cell senescence. Our previous studies have shown that deficiency of DHCR24, a gene involved in lipid metabolism, promotes endothelial cell senescence. However, how DHCR24 participates in endothelial cell senescence through lipid metabolism remains...

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Literature Corpus work
c222559c-e15a-5abe-b313-bb4edf7784ca
DOI
10.21203/rs.3.rs-10153116/v1
Open publication

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