Article
Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice.
Circulation - 9 Mar 2010
Ii Masaaki, Takeshita Kyosuke, Ibusuki Kayoko, Luedemann Corinne, Wecker Andrea, Eaton Elizabeth, Thorne Tina, Asahara Takayuki, Liao James K, Losordo Douglas W
Abstract excerpt
BACKGROUND: Little is known about the role of endothelial progenitor cells (EPCs) in atherosclerosis. Accordingly, we performed a series of assessments with hypercholesterolemic (apolipoprotein E-null [ApoE(-/-)]) and wild-type (WT) mice to evaluate how cholesterol influences reendothelialization, atherosclerosis, and EPC function after arterial injury. METHODS AND RESULTS: Unexpectedly, reendothelialization...
Topics
- Animals
- Apolipoproteins E
- Atherosclerosis
- Bone Marrow Transplantation
- Carotid Artery Injuries
- Cell Movement
- Cholesterol
- Endothelial Cells
- Gene Expression Regulation
- Genotype