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Article

Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells.

Cellular & molecular biology letters - 1 Jan 2009

Limaye Vidya, Xia Pu, Hahn Chris, Smith Malcolm, Vadas Mathew A, Pitson Stuart M, Gamble Jennifer R

Abstract excerpt

Sphingosine kinase-1 (SK1) promotes the formation of sphingosine-1-phosphate (S1P), which has potent pro-inflammatory and pro-angiogenic effects. We investigated the effects of raised SK1 levels on endothelial cell function and the possibility that this signaling pathway is activated in rheumatoid arthritis. Human umbilical vein endothelial cells with 3- to 5-fold SK1 (EC(SK)) overexpression were generated by...

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Identifiers

PMID: 19238330
DOI: 10.2478/s11658-009-0009-1
PMCID: PMC6275620

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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