Article
Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2009
Mansour Marc R, Sulis Maria L, Duke Veronique, Foroni Letizia, Jenkinson Sarah, Koo Kenneth, Allen Christopher G, Gale Rosemary E, Buck Georgina, Richards Sue, Paietta Elisabeth, Rowe Jacob M, Tallman Martin S, Goldstone Anthony H, Ferrando Adolfo A, Linch David C
Abstract excerpt
PURPOSE: Notch pathway activation by mutations in either NOTCH1 and/or FBXW7 is one of the most common molecular events in T-cell acute lymphoblastic leukemia (T-ALL) and, in pediatric disease, predicts for favorable outcome. Their prognostic significance in adult T-ALL is unclear. We sought to evaluate the outcome according to mutation status of patients with adult T-ALL treated on the United Kingdom Acute...
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