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Article

Changes in the HIV type 1 envelope gene from non-subtype B HIV type 1-infected children in Kenya.

AIDS research and human retroviruses - 1 Feb 2009

Lwembe Raphael, Lihana Raphael W, Ochieng' Washingtone, Panikulam Annie, Mongoina Charles O, Palakudy Tresa, de Koning Heleen, Ishizaki Azumi, Kageyama Seiji, Musoke Rachel, Owens Mary, Songok Elijah M, Okoth Frederick A, Ichimura Hiroshi

Abstract excerpt

A switch of coreceptor usage from CCR5 to CXCR4 occurs in about half of HIV-1-infected individuals in the natural course of infection. To investigate whether antiretroviral therapy (ART) enhances the coreceptor switch of HIV-1, we genotypically analyzed the env-V3 amino acid sequences from 81 HIV-1-infected children in Kenya whose plasma samples were obtained between 2000 and 2007. Of 41 children on ART, 35 had...

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Share to Antiretroviral Therapy, Highly Active
Share to CD4 Lymphocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV Infections

Share to Receptors, HIV

Share to Viral Load

Share to Virus Internalization

Source

Identifiers

PMID: 19108688
DOI: 10.1089/aid.2008.0144

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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