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Article

R5 to X4 switch of the predominant HIV-1 population in cellular reservoirs during effective highly active antiretroviral therapy.

Journal of acquired immune deficiency syndromes (1999) - 1 Apr 2005

Delobel Pierre, Sandres-Sauné Karine, Cazabat Michelle, Pasquier Christophe, Marchou Bruno, Massip Patrice, Izopet Jacques

Abstract excerpt

HIV-1 coreceptor usage plays a critical role for virus tropism and pathogenesis. A switch from CCR5 to CXCR4-using viruses can occur in the natural course of infection and correlates with subsequent disease progression. To investigate whether HIV-1 genetic evolution might lead to changes in virus coreceptor usage during highly active antiretroviral therapy (HAART), a longitudinal genotypic analysis of the virus...

Read the complete abstract on PubMed

Topics

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Share to Acquired Immunodeficiency Syndrome
Share to Antiretroviral Therapy, Highly Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Lymphocyte Count

Share to CD4-Positive T-Lymphocytes

Share to Disease Reservoirs

Share to Gene Products, env

Share to Genes, env

Share to Viral Load

Source

Identifiers

PMID: 15764954
DOI: 10.1097/01.qai.0000152835.17747.47

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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