Article
Evolution of the human immunodeficiency virus type 2 envelope in the first years of infection is associated with the dynamics of the neutralizing antibody response.
Retrovirology - 24 Oct 2013
Rocha Cheila, Calado Rita, Borrego Pedro, Marcelino José Maria, Bártolo Inês, Rosado Lino, Cavaco-Silva Patrícia, Gomes Perpétua, Família Carlos, Quintas Alexandre, Skar Helena, Leitner Thomas, Barroso Helena, Taveira Nuno
Abstract excerpt
BACKGROUND: Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4⁺ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and...
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