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Article

Intrinsic Obstacles to Human Immunodeficiency Virus Type 1 Coreceptor Switching

25 Jun 2004

Abstract excerpt

The natural evolution of human immunodeficiency virus type 1 infection often includes a switch in coreceptor preference late in infection from CCR5 to CXCR4, a change associated with expanded target cell range and worsened clinical prognosis. Why coreceptor switching takes so long is puzzling, since it requires as few as one to two mutations. Here we report three obstacles that impede the CCR5-to-CXCR4 switch....

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PMID: 15220431
DOI: 10.1128/jvi.78.14.7565-7574.2004

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