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Article

Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation.

Hepatology (Baltimore, Md.) - 1 Feb 2009

Ney Jasmin T, Schmidt Thomas, Kurts Christian, Zhou Qi, Eckert Dawid, Felsher Dean W, Schorle Hubert, Knolle Percy, Tüting Thomas, Barchet Winfried, Büttner Reinhard, Limmer Andreas, Gütgemann Ines

Abstract excerpt

The reason the adaptive immune system fails in advanced liver tumors is largely unclear. To address this question, we have developed a novel murine model that combines c-myc-induced autochthonous tumorigenesis with expression of a cognate antigen, ovalbumin (OVA). When c-myc/OVA transgenic mice were crossed with liver-specific inducer mice, multifocal hepatocellular carcinomas co-expressing OVA developed in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19105207
DOI: 10.1002/hep.22652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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