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Article

The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose.

Molecular therapy : the journal of the American Society of Gene Therapy - 5 Apr 2017

Kumar Sandeep R P, Hoffman Brad E, Terhorst Cox, de Jong Ype P, Herzog Roland W

Abstract excerpt

The liver continuously receives antigens from circulation and the gastrointestinal tract. A complex immune regulatory system has evolved in order to both limit inflammation and promote tolerance in the liver. Although in situ immune tolerance mechanisms enable successful gene therapy and liver transplantation, at the same time they facilitate chronic infections by pathogens such as hepatitis viruses. It is,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28284982
DOI: 10.1016/j.ymthe.2017.02.014
PMCID: PMC5383644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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