Article
Developmental context determines latency of MYC-induced tumorigenesis.
PLoS biology - 1 Nov 2004
Beer Shelly, Zetterberg Anders, Ihrie Rebecca A, McTaggart Ryan A, Yang Qiwei, Bradon Nicole, Arvanitis Constadina, Attardi Laura D, Feng Sandy, Ruebner Boris, Cardiff Robert D, Felsher Dean W
Abstract excerpt
One of the enigmas in tumor biology is that different types of cancers are prevalent in different age groups. One possible explanation is that the ability of a specific oncogene to cause tumorigenesis in a particular cell type depends on epigenetic parameters such as the developmental context. To address this hypothesis, we have used the tetracycline regulatory system to generate transgenic mice in which the...
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