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Article

Gene-gene interaction associated with neural reward sensitivity.

Proceedings of the National Academy of Sciences of the United States of America - 8 May 2007

Yacubian Juliana, Sommer Tobias, Schroeder Katrin, Gläscher Jan, Kalisch Raffael, Leuenberger Boris, Braus Dieter F, Büchel Christian

Abstract excerpt

Reward processing depends on dopaminergic neurotransmission and is modulated by factors affecting dopamine (DA) reuptake and degradation. We used fMRI and a guessing task sensitive to reward-related activation in the prefrontal cortex and ventral striatum to study how individual variation in genes contributing to DA reuptake [DA transporter (DAT)] and degradation [catechol-o-methyltransferase (COMT)] influences...

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Source

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Identifiers

PMID: 17483451
DOI: 10.1073/pnas.0702029104
PMCID: PMC1864910

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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