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Article

Multilocus genetic composite reflecting dopamine signaling capacity predicts reward circuitry responsivity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Jul 2012

Stice Eric, Yokum Sonja, Burger Kyle, Epstein Leonard, Smolen Andy

Abstract excerpt

The objective of the study was to test the hypotheses that humans with genotypes putatively associated with low dopamine (DA) signaling capacity, including the TaqIA A1 allele, DRD2-141C Ins/Ins genotype, DRD4 7-repeat or longer allele, DAT1 10-repeat allele, and the Met/Met COMT genotype, and with a greater number of these genotypes per a multilocus composite, show less responsivity of reward regions that...

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Source

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Identifiers

PMID: 22815523
DOI: 10.1523/JNEUROSCI.1506-12.2012
PMCID: PMC3479152

Genes

DRD4
COMT
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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