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Article

Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta.

European journal of immunology - 1 Jan 2008

Ferwerda Gerben, Kramer Matthijs, de Jong Dirk, Piccini Alessandra, Joosten Leo A, Devesaginer Isabel, Girardin Stephen E, Adema Gosse J, van der Meer Jos W M, Kullberg Bart-Jan, Rubartelli Anna, Netea Mihai G

Abstract excerpt

Synthesis and release of pro-inflammatory cytokines, such as IL-1beta, play a crucial role in the intestinal inflammation that characterizes Crohn's disease. Mutations in the nucleotide oligomerization domain 2 (NOD2) gene are associated with an increased risk of Crohn's disease. Although it is known that NOD2 mediates cytokine responses to muramyl dipeptide (MDP), it is yet unclear whether NOD2 stimulation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18157816
DOI: 10.1002/eji.200737103

Genes

NOD2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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