Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis

Abstract excerpt

The mechanisms underlying the susceptibility of individuals with caspase recruitment domain 15 (CARD15) mutations and corresponding abnormalities of nucleotide-binding oligomerization domain 2 (NOD2) protein to Crohn disease are still poorly understood. One possibility is based on previous studies showing that muramyl dipeptide (MDP) activation of NOD2 negatively regulates TLR2 responses and that absence of such...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Helicobacter pylori-related gastroenterology studies
• Share to Immune Response and Inflammation
• Share to Inflammatory Bowel Disease