Article
Hypermethylation of the DNA repair gene MGMT: association with TP53 G:C to A:T transitions in a series of 469 nervous system tumors.
Mutation research - 4 Oct 2004
Bello M Josefa, Alonso M Eva, Amiñoso Cinthia, Anselmo Nilson P, Arjona Dolores, Gonzalez-Gomez Pilar, Lopez-Marin Isabel, de Campos Jose M, Gutierrez Manuel, Isla Alberto, Kusak M Elena, Lassaletta Luis, Sarasa Jose L, Vaquero Jesus, Casartelli Cacilda, Rey Juan A
Abstract excerpt
O6-methylguanine-DNA methyltransferase (MGMT) plays a major role in repairing DNA damage from alkylating agents. By removing alkyl groups from the O6-position in guanine, MGMT can prevent G:C to A:T transition mutations, a type of variation frequently involving TP53 mutations in brain tumors. Promoter hypermethylation of CpG islands in tumor-related genes can lead to their transcriptional inactivation, and this...
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